Ergot alkaloids: From witchcraft till in silico analysis. Multi-receptor analysis of ergotamine metabolites
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چکیده
منابع مشابه
Ergot alkaloids: From witchcraft till in silico analysis. Multi-receptor analysis of ergotamine metabolites
The term Ergot is referred to the sclerotium of ascomycetes - a protective kernel produced during resting stage of some fungi - which replaces seeds of susceptible cereals and plants intended for human and animal diet. It contains various composition of tryptophan-derived toxins defined ergot alkaloids. Since sclerotia can be harvested and milled together with cereals, they represent a source o...
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The principles and application of established and newer methods for the quantitative and semi-quantitative determination of ergot alkaloids in food, feed, plant materials and animal tissues are reviewed. The techniques of sampling, extraction, clean-up, detection, quantification and validation are described. The major procedures for ergot alkaloid analysis comprise liquid chromatography with ta...
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15 صفحه اولSynthesis of Ergot Alkaloids from Tryptophan
The first total syntheses of lysergine and setoclavine are described, as well as a new and efficient synthesis of lysergic acid. The starting material for these syntheses is tryptophan, protected as its dihydro, dibenzoyl derivative. This material is dehydrated to the corresponding azlactone, which undergoes stereoselective intramolecular Friedel-Crafts acylation to give a tricyclic ketone inte...
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ژورنال
عنوان ژورنال: Toxicology Reports
سال: 2015
ISSN: 2214-7500
DOI: 10.1016/j.toxrep.2015.03.005